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LCB 03-0110 dihydrochloride
CAS No. 1962928-28-4
LCB 03-0110 dihydrochloride( LCB03-0110 )
Catalog No. M13080 CAS No. 1962928-28-4
LCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 160 | Get Quote |
|
| 5MG | 246 | Get Quote |
|
| 10MG | 358 | Get Quote |
|
| 25MG | 599 | Get Quote |
|
| 50MG | 852 | Get Quote |
|
| 100MG | 1152 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLCB 03-0110 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family.
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DescriptionLCB 03-0110 is a potent, ATP-competitive inhibitor of Discoidin domain receptor (DDR) family and c-Src tyrosine kinase family, as well as Btk and Syk; potently inhibits the activated tyrosine kinase activity of DDR2 (IC50=6 nM), and nonactivated form of DDR2 (IC50=145 nM); suppresses collagen-induced autophosphorylation of DDR1 and DDR2 with IC50 of 164 and 171 nM in cell-based assays; inhibits all eight Src family kinases with IC50 of 2-20 nM; suppresses the proliferation and migration of primary dermal fibroblasts induced by TGF β1 and type I collagen (IC50=194 nM), inhibits cell migration and nitric oxide, iNOS, COX2, and TNF-α synthesis in LPS-activated J774A.1 macrophage cells; suppresses hypertrophic scar formation in wound healing models.
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In Vitro——
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In Vivo——
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SynonymsLCB03-0110
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PathwayTyrosine Kinase
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TargetDDR
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RecptorDDR
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Research Area——
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Indication——
Chemical Information
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CAS Number1962928-28-4
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Formula Weight490.443
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Molecular FormulaC24H25Cl2N3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name3-[[2-[3-(4-Morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenol dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sun X, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9.
2. Jung SH, et al. Br J Dermatol. 2013 Jan;168(1):112-9.
3. Kim BH, et al. Exp Dermatol. 2015 Jul;24(7):503-9.
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